Curriculum Vitae

Randall S. Hewes, Ph.D.

  • 1988-1993   Ph.D., Zoology, University of Washington
  • 1984-1988   B.A., Biology, Magna Cum Laude, Carleton College
Academic Positions
  • 2017-pres    Dean, Graduate College, University of Oklahoma (OU)
  • 2016-2017   Interim Dean, Graduate College, University of Oklahoma, OU
  • 2016            Senior Associate Dean, Graduate College, OU
  • 2011-2015   Chair, Department of Biology, OU
  • 2015-pres    Professor, Department of Biology, OU
  • 2008-2011   Assistant Chair, Department of Zoology, OU
  • 2007-2015   Associate Professor, Department of Biology (formerly Zoology), OU
  • 2007-2010   Adjunct Associate Professor, Dept. of Cell Biology, OU Health Sciences Center (OUHSC)
  • 2002-2007   Adjunct Assistant Professor, Dept. of Cell Biology, OUHSC
  • 2001-2007   Assistant Professor, Department of Zoology, OU
  • 1998-2001   Research Associate, Washington University School of Medicine (WUSM), Department of Anatomy and Neurobiology
  • 1995-1997   American Cancer Society Postdoctoral Fellow, WUSM
  • 1993-1994   Postdoctoral Fellow, WUSM
Research Interests
  • Genetic and molecular pathways controlling differentiation and hormonally regulated plasticity of neuroendocrine cells
  • Control of neuropeptide secretion
  • Cellular and molecular mechanisms of hormone action in neuroendocrine systems
Selected Honors, Awards, Fellowships
  • 2008   Favorite OU Professor, chosen by OU Women’s Soccer Players
  • 2007   Kinney-Sugg Outstanding Professor, OU College of Arts and Sciences
  • 2002   OU Nominee (Norman campus), 2003 Searle Scholars Program
  • 2002   Poster Award, Gordon Research Conference, Hormonal and Neural Peptide Biosynthesis
  • 2001   O’Leary Prize Postdoctoral Finalist, for Outstanding Neuroscience Research, WUSTL
  • 1995   American Cancer Society Postdoctoral Fellowship
  • 1994   Lucille P. Markey Special Emphasis Pathway in Human Pathobiology Fellowship, WUSTL (declined for ACS Fellowship)
  • 1988   Honorable Mention, NSF Graduate Fellowship
  • 1988   Sigma Xi
  • 1987   Casey Jarchow Scholar, Carleton
  • 1984   National Merit Scholarship
  • 1984   Rensselaer Polytechnic Institute Award

Google Scholar Profile
Peer-Reviewed Journal Articles

Gu, T.δ, Zhao, T.δ, Kohli, U., & Hewes, R.S. (2017). The large and small SPEN family proteins stimulate axon outgrowth during neurosecretory cell remodeling in Drosophila. Developmental Biology 431(2):226-238. δJoint first authors. LINK

Chen, D., Gu, T., Pham, T.N., Zachary, M.J., Hewes, R.S. (2017). Regulatory mechanisms of metamorphic neuronal remodeling revealed through a genome-wide modifier screen in Drosophila. Genetics 206(3):1429-1443. LINK

Chen, D., Qu, C., Bjorum, S.M., Beckingham, K.M., & Hewes, R.S. (2014). Neuronal remodeling during metamorphosis is regulated by the alan shepard (shep) gene in Drosophila melanogaster. Genetics 197(4):1267-1283. LINK | Journal Highlight

Bulgari, D., Zhou, C. Hewes, R.S., Deitcher, D.L., & Levitan, E.S. (2014). Vesicle capture, not delivery, scales up neuropeptide storage in neuroendocrine terminals. Proceedings of the National Academy of Sciences, USA 111(9):3597-3601. LINK

Gu, T., T. Zhao, & R.S. Hewes. (2014). Insulin signaling regulates neurite growth during metamorphic neuronal remodeling. Biology Open 3(1):81-93. LINK

Gauthier, S., Van Haaften, E., Cherbas, L., Cherbas, P., Hewes, R.S. (2012). Cryptocephal, the Drosophila ATF4, is a specific coactivator for ecdysone receptor isoform B2. PLoS Genetics 8(8):1-8. LINK

Shakiryanova, D., Zettel, G., Gu, T., Hewes, R.S., & Levitan, E.S. (2011). Synaptic neuropeptide release induced by octopamine without Ca2+ entry into the nerve terminal. Proceedings of the National Academy of Sciences, USA 108(11):4477-4481. LINK

R.S. Hewes (2008). The buzz on fly neuronal remodeling. TRENDS in Endocrinology and Metabolism 19(9):317-323. LINK

Zhao, T., T. Gu, H.C. Rice, K.L. McAdams, K.M. Roark, K. Lawson, S.A. Gauthier, K.L. Reagan & R.S. Hewes (2008). A Drosophila gain-of-function screen for candidate genes involved in steroid-dependent neuroendocrine cell remodeling. Genetics 178(2):1-19. LINK

Shakiryanova, D., M. Klose, Y. Zhou, T. Gu, D.L. Deitcher, H.L. Atwood, R.S. Hewes & E.S. Levitan (2007). Presynaptic ryanodine receptor-activated calmodulin kinase II increases vesicle mobility and potentiates neuropeptide release. Journal of Neuroscience 27(29):7799-7806. LINK

Hewes, R.S., T. Gu, J.A. Brewster, C. Qu & T. Zhao (2006). Regulation of secretory protein expression in mature cells by DIMM, a bHLH neuroendocrine differentiation factor. Journal of Neuroscience 26(30):7860-7869. LINK

Gauthier and Hewes 2006 Cover photoGauthier, S.A. & R.S. Hewes (2006). Transcriptional regulation of neuropeptide and peptide hormone expression by the Drosophila dimmed and cryptocephal genes. Journal of Experimental Biology 209(10):1803-1815. LINK | Journal Highlight

Sturman, D.A., D. Shakiryanova, R.S. Hewes, D.L. Deitcher & E.S. Levitan (2006). Nearly neutral secretory vesicles in Drosophila nerve terminals. Biophysical Journal 90(6):L45-L47. LINK

Shakiryanova, D., A. Tully, R.S. Hewes, D.L. Deitcher & E.S. Levitan (2005). Activity-dependent liberation of synaptic neuropeptide vesicles. Nature Neuroscience 8(2):173-178. LINK

Hewes, R.S., D. Park, S.A. Gauthier, A.M. Schaefer & P.H. Taghert (2003). The bHLH protein Dimmed controls neuroendocrine cell differentiation in Drosophila. Development 130(9):1771-1781. LINK

Taghert, P.H., R.S. Hewes, J.H. Park, M.A. O’Brien, M. Han & M.E. Peck (2001). Multiple amidated neuropeptides are required for normal circadian locomotor rhythms in Drosophila. Journal of Neuroscience 21(17):6673-6686. LINK

Hewes, R.S. & P.H. Taghert (2001). Neuropeptides and neuropeptide receptors in the Drosophila melanogaster genome. Genome Research 11(6):1126-1142. LINK

Hewes, R.S., A.M. Schaefer & P.H. Taghert (2000). The cryptocephal gene (Drosophila ATF4) encodes multiple basic-leucine zipper proteins controlling molting and metamorphosis in Drosophila. Genetics 155(4):1711-1723. LINK

Hewes, R.S. (1999). Voltage-dependent ionic currents in the ventromedial eclosion hormone neurons of Manduca sexta. Journal of Experimental Biology 202(Pt 17):2371-2383. LINK

Hewes, R.S., E.C. Snowdeal III, Y. Zhong & P.H. Taghert (1998). Functional redundancy of FMRFamide-related peptides at the Drosophila larval neuromuscular junction. Journal of Neuroscience 18(18):7138-7151. LINK

Hewes, R.S. & J.W. Truman (1994). Steroid regulation of excitability in identified insect neurosecretory cells. Journal of Neuroscience 14(3 Pt 2):1812-1819. LINK

Riddiford, L.M., R.S. Hewes & J.W. Truman (1994). Dynamics and metamorphosis of an identifiable peptidergic neuron in an insect. Journal of Neurobiology 25(7):819-830. LINK

Murray, J.A., R.S. Hewes & A.O.D. Willows (1992). Water-flow sensitive pedal neurons in Tritonia: role in rheotaxis. Journal of Comparative Physiology A 171(3):373-385. LINK

Hewes, R.S. & J.W. Truman (1991). The roles of central and peripheral eclosion hormone release in the control of ecdysis behavior in Manduca sexta. Journal of Comparative Physiology A 168(6):697-707. LINK

Submitted Manuscripts

Zhao, T., T. Gu, & R.S. Hewes. The large and small SPEN family proteins stimulate axon outgrowth during neurosecretory cell remodeling in Drosophila. Submitted, in revision.

Zhao, T., T. Gu, K.L. McAdams, E. Moran, & R.S. Hewes. The Split ends (SPEN) transcriptional cofactor suppresses Myosin II-dependent axon outgrowth during neurosecretory cell remodeling in Drosophila. Submitted, in revision.

Peer-Reviewed Book Chapters

Truman, J.W., R.S. Hewes & J. Ewer (1994). Action and interaction of peptides in regulating ecdysis behavior in insects. In Proceedings of the International Congress of Insect Neurobiology and Neurochemistry, M.J. Loeb, editor. CRC Press, Boca Raton, FL.

Truman, J.W., F.M. Horodyski, R.S. Hewes & L.M. Riddiford (1991). Eclosion hormone: From genes to behavior. In Insect neuropeptides: Chemistry, biology, and action, J.J. Menn, T.J. Kelly, E.P. Masler, editors. ACS Books, Washington, pp. 95-99.